Dr. Julia Duda

• Since April 2024: Postdoctoral Researcher
• 2020-2024: Doctoral Student
  Doctoral Thesis: Modeling Approaches for Dose-Response Data in Toxicology
• 2023 (May-July): Visiting scholar at the National Institute of Environmental Health Sciences (NIEHS), North Carolina, USA
• 2013-2019: Study of Sta­tis­tics with minor in Biostatistics at TU Dort­mund Uni­ver­sity
• Master Thesis: Model Selection and Model Averaging of Dose-Response Gene Expression Data with MCP-Mod
• 2017-2018: Year abroad at Michigan Technological University, Michigan, USA

ORCiD
GitHub

2024

Ghallab, A., González Leiva, D. F., Strängberg, E., Hofmann, U., Myllys, M., Hassan, R., Hobloss, Z., Brackhagen, L., Begher-Tibbe, B., Duda, J. C., Drenda, C., Kappenberg, F., Reinders, J., Friebel, A., Vucur, M., Turajski, M., Seddek, A., Abbas, T., Abdelmageed, N., … Hengstler, J. G. (2024). Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis. Journal of Hepatology, 80(2), 268–281. https://doi.org/10.1016/j.jhep.2023.10.035

Tug, T., Duda, J. C., Menssen, M., Bruce, S. W., Bringezu, F., Dammann, M., Frötschl, R., Harm, V., Ickstadt, K., Igl, B.-W., Jarzombek, M., Kellner, R., Lott, J., Pfuhler, S., Plappert-Helbig, U., Rahnenführer, J., Schulz, M., Vaas, L., Vasquez, M., … Ziemann, C. (2024). In vivo alkaline comet assay: statistical considerations on historical negative and positive control data. Regulatory Toxicology and Pharmacology, Article 105583. In press. https://doi.org/10.1016/j.yrtph.2024.105583

2023

Duda, J. C., Drenda, C., Kästel, H., Rahnenführer, J., Kappenberg, F. (2023). Benefit of using interaction effects for the analysis of high-dimensional time-response or dose-response data for two-group comparisons. Scientific Reports [ISSN: 2045-2322], 13(1). https://doi.org/10.1038/s41598-023-47057-0

Kappenberg, F., Duda, J. C., Schürmeyer, L., Gül, O., Brecklinghaus, T., Hengstler, J. G., Schorning, K., & Rahnenführer, J. (2023). Guidance for statistical design and analysis of toxicological dose–response experiments, based on a comprehensive literature review. Archives of Toxicology. In press. https://doi.org/10.1007/s00204-023-03561-w

Su, H., Haque, M., Becker, S., Edlund, K., Duda, J. C., Wang, Q., Reißing, J., Marschall, H., Candels, L. S., Mohamed, M., Sjöland, W., Liao, L., Drexler, S. A., Strowig, T., Rahnenführer, J., Hengstler, J. G., Hatting, M., & Trautwein, C. (2023). Long‐term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals. Liver International. In press. https://doi.org/10.1111/liv.15587

2022

Brecklinghaus, T., Albrecht, W., Duda, J. C., Kappenberg, F., Gründler, L., Edlund, K., Marchan, R., Ghallab, A., Cadenas, C., Rieck, A., Vartak, N., Tolosa, L., Castell, J. V., Gardner, I., Halilbasic, E., Trauner, M., Ullrich, A., Zeigerer, A., Demirci Turgunbayer, Ö., … , Hengstler, J. G. (2022). In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay. Toxicology Letters, 368, 33–46. https://doi.org/10.1016/j.toxlet.2022.08.006

Brecklinghaus, T., Albrecht, W., Kappenberg, F., Duda, J. C., Vartak, N., Edlund, K., Marchan, R., Ghallab, A., Cadenas, C., Günther, G., Leist, M., Zhang, M., Gardner, I., Reinders, J., Russel, F. GM., Foster, A. J., Williams, D. P., Damle-Vartak, A., Grandits, M., … , Hengstler, J. G. (2022). The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chemico-Biological Interactions, 351, Article 109728. https://doi.org/10.1016/j.cbi.2021.109728

Brecklinghaus, T., Albrecht, W., Kappenberg, F., Duda, J. C., Zhang, M., Gardner, I., Marchan, R., Ghallab, A., Turgunbayer, Ö. D., Rahnenführer, J., & Hengstler, J. G. (2022). Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes. Toxicology in Vitro, 81, Article 105344. https://doi.org/10.1016/j.tiv.2022.105344

Duda, J. C., Hengstler, J. G., & Rahnenführer, J. (2022). td2pLL: an intuitive time-dose-response model for cytotoxicity data with varying exposure durations. Computational Toxicology, 43, Article 100234. https://doi.org/10.1016/j.comtox.2022.100234

Duda, J. C., Kappenberg, F., & Rahnenführer, J. (2022). Model selection characteristics when using MCP‐Mod for dose–response gene expression data. Biometrical Journal, 64(5), 883–897. https://doi.org/10.1002/bimj.202000250

2021

Ghallab, A., Myllys, M., Friebel, A., Duda, J. C., Edlund, K., Halibasic, E., Vucur, M., Hobloss, Z., Brackhagen, L., Begher-Tibbe, B., Hassan, R., Burke, M., Genç, E., Frohwein, L. J., Hofmann, U., Holland, C. H., González Leiva, D. F., Keller, M., Seddek, A., … , Hengstler, J. G. (2021). Spatio-temporal multiscale analysis of Western diet-fed mice reveals a translationally relevant sequence of events during NAFLD progression [OnlineRessource]. Cells, 10(10), Article 2516. https://doi.org/10.3390/cells10102516

• Clinical Trials (SoSe 2024)
• Organization of Data Science in Context (WiSe 2020/2021)