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Dr. Birte Hellwig


TU Dort­mund Uni­ver­sity
Department of Sta­tis­tics
Statistical Methods in Genetics and Chemometrics
Mathematics Building, Room 728
44221 Dortmund

E-Mail: hellwigstatistik.tu-dortmundde
Phone: +49 231 755 3118

Porträtfoto von Birte Hellwig © Birte Hellwig​/​privat
  • Dr. rer. nat. (Statistics), TU Dortmund University, 2018
    Thesis: Klassifikation von Brustkrebspatientinnen anhand vorausgewählter Gene mit charakteristischer Expressionsverteilung
  • Diploma (Statistics), TU Dortmund University, 2009
    Diploma Thesis: Genexpressionsdaten als Kovariablen in Überlebenszeitmodellen für Brustkrebspatientinnen
Scientific Work
  • since April 2018: Postdoc at the Department of Statistics
  • May 2011 - March 2018: Research Assistant and doctoral student at the Department of Statistics
  • April 2009 - April 2011: Research Assistant at Leibniz Research Centre for Working Environment and Human Factors (IfADo)
Current research project

DFG-Project HE8508/2-1: Statistical quantification and modelling of changes in gene expression and biological processes in stem cell differentiation, Individual grant for funding of own position (Project number 491064493, duration: 01/2022-12/2024)

Previous project work
  • July 2017 - June 2019: BMBF project: StemNet: iPS cell derived human hepatocytes: improved reprogramming and development of in vitro disease models, subproject 4
  • May 2011 - June 2017: DFG-Project RA 870/5-1: Improved prognostic signatures from microarray studies by selecting genes with characteristic distributions
Focus of research
  • Statistical analysis of gene expression data
  • Survival Analysis


Keller, M., Rohlf, K., Glotzbach, A., Leonhardt, G., Lüke, S., Derksen, K., Demirci, Ö., Demirci, Ö., Göçener, D., AlWahsh, M., Lambert, J., Lindskog, C., Schmidt, M., Brenner, W., Baumann, M., Zent, E., Zischinsky, M.-L., Hellwig, B., Madjar, K., … Marchan, R. (2023). Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth. Journal of Experimental & Clinical Cancer Research, 42, Article 25.


Nell, P., Kattler, K., Feuerborn, D., Hellwig, B., Rieck, A., Salhab, A., Lepikhov, K., Gasparoni, G., Thomitzek, A., Belgasmi, K., Blüthgen, N., Morkel, M., Küppers-Munther, B., Godoy, P., Hay, D. C., Cadenas, C., Marchan, R., Vartak, N., Edlund, K., … Hengstler, J. G. (2022). Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells. Journal of Hepatology. In press.


Lucendo-Villarin, B., Nell, P., Hellwig, B., Filis, P., Feuerborn, D., O’Shaughnessy, P. J., Godoy, P., Rahnenführer, J., Hengstler, J. G., Cherianidou, A., Sachinidis, A., Fowler, P. A., & Hay, D. C. (2020). Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells [OnlineRessource]. EXCLI Journal : Experimental and Clinical Sciences, 19, 1459–1476.


Cadenas, C., Vosbeck, S., Edlund, K., Grgas, K., Madjar, K., Hellwig, B., Adawy, A., Glotzbach, A., Stewart, J. D., Lesjak, M. S., Franckenstein, D., Claus, M., Hayen, H., Schriewer, A., Gianmoena, K., Thaler, S., Schmidt, M., Micke, P., Pontén, F., … Hengstler, J. G. (2019). LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer. International Journal of Cancer, 145(4), 901–915.

Hellwig, B. (2019). Highlight report: tumor infiltrating lymphocytes in breast cancer. EXCLI Journal : Experimental and Clinical Sciences, 18, 129–131.

Klindt, C., Reich, M., Hellwig, B., Stindt, J., Rahnenführer, J., Hengstler, J. G., Köhrer, K., Schoonjans, K., Häussinger, D., & Keitel, V. (2019). The G protein-coupled bile  acid receptor TGR5 (Gpbar1) modulates endothelin-1 signaling in liver [OnlineRessource]. Cells, 8(11), 1–21.


Godoy, P., Schmidt-Heck, W., Hellwig, B., Nell, P., Feuerborn, D., Rahnenführer, J., Kattler, K., Walter, J., Blüthgen, N., & Hengstler, J. G. (2018). Assessment of stem cell differentiation based on genome-wide expression profiles. Philosophical Transactions of the Royal Society of London B, 373(1750).

Grinberg, M., Stöber, R., Albrecht, W., Edlund, K., Schug, M., Godoy, P., Cadenas, C., Marchan, R., Lampen, A., Braeuning, A., Buhrke, T., Leist, M., Oberemm, A., Hellwig, B., Kamp, H., Gardner, I., Escher, S., Taboureau, O., Aguayo-Orozco, A., … Hengstler, J. G. (2018). Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes. Archives of Toxicology, 92(12), 3517–3533.


Gogiashvili, M., Edlund, K., Gianmoena, K., Marchan, R., Brik, A., Andersson, J. T., Lambert, J., Madjar, K., Hellwig, B., Rahnenführer, J., Hengstler, J. G., Hergenröder, R., & Cadenas, C. (2017). Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway. Analytical & Bioanalytical Chemistry, 409(6), 1591–1606.

Hellwig, B. (2017). Klassifikation von Brustkrebspatientinnen anhand vorausgewählter Gene mit charakteristischer Expressionsverteilung (Publisher’s Version) [Universitätsbibliothek Dortmund].


Hellwig, B., Madjar, K., Edlund, K., Marchan, R., Cadenas, C., Heimes, A.-S., Almstedt, K., Lebrecht, A., Sicking, I., Battista, M. J., Micke, P., Schmidt, M., Hengstler, J. G., & Rahnenführer, J. (2016). Epsin family member 3 and ribosome-related genes are associated with late metastasis in estrogen receptor-positive breast cancer and long-term survival in non-small cell lung cancer using a genome-wide identification and validation strategy. PLOS ONE, 11(12), 1–18.


Lohr, M., Hellwig, B., Edlund, K., Mattsson, J. S. M., Botling, J., Schmidt, M., Hengstler, J. G., Micke, P., & Rahnenführer, J. (2015). Identification of sample annotation errors in gene expression datasets. Archives of Toxicology, 89(12), 2265–2272.


Cadenas, C., Sandt, L. van de, Edlund, K., Lohr, M., Hellwig, B., Marchan, R., Schmidt, M., Rahnenführer, J., Oster, H., & Hengstler, J. G. (2014). Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle, 13(20), 3282–3291.

Godoy, P., Cadenas, C., Hellwig, B., Marchan, R., Stewart, J., Reif, R., Lohr, M., Gehrmann, M., Rahnenführer, J., Schmidt, M., & Hengstler, J. G. (2014). Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response. Breast Cancer : The Journal of the Japanese Breast Cancer Society, 21(4), 491–499.

Lindskog, C., Fagerberg, L., Hallström, B., Edlund, K., Hellwig, B., Rahnenführer, J., Kampf, C., Uhlén, M., Pontén, F., & Micke, P. (2014). The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. The FASEB Journal / Federation of American Societies for Experimental Biology, 28(12), 5184–5196.


Botling, J., Edlund, K., Lohr, M., Hellwig, B., Holmberg, L., Lambe, M., Berglund, A., Ekman, S., Bergqvist, M., Pontén, F., König, A., Fernandes, O., Karlsson, M., Helenius, G., Karlsson, C., Rahnenführer, J., Hengstler, J. G., & Micke, P. (2013). Biomarker discovery in non–small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation. Clinical Cancer Research, 19(1), 194–204.

Lohr, M., Edlund, K., Botling, J., Hammad, S., Hellwig, B., Othman, A., Berglund, A., Lambe, M., Holmberg, L., Ekman, S., Bergqvist, M., Pontén, F., Cadenas, C., Marchan, R., Hengstler, J. G., Rahnenführer, J., & Micke, P. (2013). The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer. Cancer Letters, 333(2), 222–228.


Cadenas, C., Vosbeck, S., Hein, E.-M., Hellwig, B., Langer, A., Hayen, H., Franckenstein, D., Büttner, B., Hammad, S., Marchan, R., Hermes, M., Selinski, S., Rahnenführer, J., Peksel, B., Török, Z., Vígh, L., & Hengstler, J. G. (2012). Glycerophospholipid profile in oncogene-induced senescence. Biochimica et Biophysica Acta : BBA, 1821(9), 1256–1268.

Heise, T., Schug, M., Storm, D., Ellinger-Ziegelbauer, H., Ahr, H.-J., Hellwig, B., Rahnenführer, J., Ghallab, A., Guenther, G., Sisnaiske, J., Reif, R., Godoy, P., Mielke, H., Gundert-Remy, U., Lampen, A., Oberemm, A., & Hengstler, J. G. (2012). In vitro, in vivo correlation of gene expression alterations induced by liver carcinogens. Current Medicinal Chemistry, 19(11), 1721–1730.

Lohr, M., Köllmann, C., Freis, E., Hellwig, B., Hengstler, J. G., Ickstadt, K., & Rahnenführer, J. (2012). Optimal strategies for sequential validation of significant features from high-dimensional genomic data. Journal of Toxicology and Environmental Health A, 75(8–10), 447–460.

Schmidt, M., Hellwig, B., Hammad, S., Othman, A., Lohr, M., Chen, Z., Böhm, D., Gebhard, S., Petry, I. B., Lebrecht, A., Cadenas, C., Marchan, R., Stewart, J. D., Solbach, C., Holmberg, L., Edlund, K., Kultima, H. G., Rody, A., Berglund, A., … Hengstler, J. G. (2012). A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors. Clinical Cancer Research, 18(9), 2695–2703.

Siggelkow, W., Boehm, D., Gebhard, S., Battista, M., Sicking, I., Lebrecht, A., Solbach, C., Hellwig, B., Rahnenführer, J., Koelbl, H., Gehrmann, M., Marchan, R., Cadenas, C., Hengstler, J. G., & Schmidt, M. (2012). Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients [OnlineRessource]. BMC Cancer, 12(1), 1–11.


Brase, J. C., Schmidt, M., Fischbach, T., Sültmann, H., Bojar, H., Kölbl, H., Hellwig, B., Rahnenführer, J., Hengstler, J. G., & Gehrmann, M. C. (2010). ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction. Clinical Cancer Research, 16(8), 2391–2401.

Hellwig, B., Hengstler, J. G., Schmidt, M., Gehrmann, M. C., Schormann, W., & Rahnenführer, J. (2010). Comparison of scores for bimodality of gene expression distributions and genome wide evaluation of the prognostic relevance of high scoring genes. BMC Bioinformatics, 11, 276-1-276–18.


Freis, E., Selinski, S., Weibert, B., Krahn, U., Schmidt, M., Gehrmann, M. C., Hermes, M., Maccoux, L., West, J., Schwender, H., Rahnenführer, J., Hengstler, J. G., & Ickstadt, K. (2009). Effects of metagene calculation on survival: an integrative approach using cluster and promoter analysis. In M. Grzegorczyk, J. Rahnenführer, T. Manninen, C. Wiuf, H. Lähdesmäki, M. Ahdesmäki, M.-L. Linne, & O. Yli-Harja (Eds.), Sixth International Workshop on Computational Systems Biology (WCSB 2009) (Publisher’s Version, Vol. 48, pp. 47–50). TICSP.

  • Data Science in Context (WiSe 2021/22)
  • Introductory Case Studies (WiSe 2021/22)
  • Tutorial for the lecture Klinische Studien (SuSe 2021)
  • Introductory Case Studies (WiSe 2020/21)
  • Tutorial for the lecture Klinische Studien (SuSe 2020)
  • Tutorial for the lecture Statistics in Toxicology (WiSe 2019/20)
  • WRUMS-HelpDesk (WiSe 2019/20)

Location & approach

The campus of TU Dort­mund Uni­ver­sity is located close to interstate junction Dort­mund West, where the Sauerlandlinie A45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B1 / A40. The best interstate exit to take from A45 is “Dort­mund-Eichlinghofen” (closer to South Cam­pus), and from B1 / A40 “Dort­mund-Dorstfeld” (closer to North Cam­pus). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B1-bridge leading into Dort­mund.

For travelling to the Department of Statistics, convenient parking places can be found at Vogelpothsweg (Gates 21 / 24) or alternatively at the Otto-Hahn-Straße (Gates 28 / 30 / 35).

TU Dort­mund Uni­ver­sity has its own train station (“Dort­mund Uni­ver­si­tät”). From there, suburban trains (S-Bahn) leave for Dort­mund main station (“Dort­mund Hauptbahnhof”) and Düsseldorf main station via the “Düsseldorf Airport Train Station” (take S-Bahn number 1, which leaves every 15 or 30 minutes). The uni­ver­si­ty is easily reached from Bo­chum, Essen, Mülheim an der Ruhr and Duis­burg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station “Stadtgarten”, usually lines U41, U45, U 47 and U49. At “Stadtgarten” you switch trains and get on line U42 towards “Hombruch”. Look out for the Station “An der Palmweide”. From the bus stop just across the road, busses bound for TU Dort­mund Uni­ver­sity leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop “Dort­mund Kampstraße”. From there, take U43 or U44 to the stop “Dort­mund Wittener Straße”. Switch to bus line 447 and get off at “Dort­mund Uni­ver­si­tät S”.

The H-Bahn is one of the hallmarks of TU Dort­mund Uni­ver­sity. There are two stations on North Cam­pus. One (“Dort­mund Uni­ver­si­tät S”) is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the “Technologiepark” and (via South Cam­pus) Eichlinghofen. The other station is located at the dining hall at North Cam­pus and offers a direct connection to South Cam­pus every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

Interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

Campus Lageplan Zum Lageplan