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Department of Statistics
Studenten im Sommer auf dem Campus Nord, rote Zahnräder im Hintergrund © Roland Baege​/​TU Dortmund
Postdoc

Dr. Franziska Kappenberg

Contact

TU Dort­mund Uni­ver­sity
Department of Sta­tis­tics
Statistical Methods in Genetics and Chemometrics
Mathematics Building, Room 713
44221 Dortmund
Germany

E-Mail: kappenbergstatistik.tu-dortmundde
Phone: +49 231 755 5908

Portrait photo of Franziska Kappenberg © Franziska Kappenberg​/​private
  • Dr. rer. nat (Statistics): TU Dortmund University, 2021
    Thesis: Statistical approaches for calculating alert concentrations from cytotoxicity and gene expression data
  • M.Sc. (Statistics): TU Dortmund University, 2018
    Master thesis: Vorhersage von Lebertoxizität aus Genexpressionsdaten
  • B.Sc. (Mathematics): Rheinische Friedrich-Wilhelms-Universität Bonn, 2015
    Bachelor thesis: Das Gesetz des iterierten Logarithmus für die Irrfahrt auf dem unendlichen Perkolationscluster

Scientific Work

  • since April 2021: Postdoc at the Department of Statistics
  • April 2018 - March 2021: Research Assistant and doctoral student at the Department of Statistics
  • August 2017 - March 2017: Student research assistant at the Department of Statistics
  • Analysis of gene expression data
  • Statistical methods in toxicology
  • Modeling of dose-response curves
  • Classification and prediction of liver and neurotoxicity

Previous project work:

  • Since 2021: DFG-funded research training group 2624 "Biostatistical Methods for High-Dimensional Data in Toxicology"
  • 2020: BMBF project "SysDT"
  • 2018-2020: BMBF project "LivSys Transfer"

GitHub Profil

ORCiD
GoogleScholar

2023

Almstedt, K., Krauthauser, L., Kappenberg, F., Wagner, D.-C., Heimes, A.-S., Battista, M. J., Anic, K., Krajnak, S., Lebrecht, A., Schwab, R., Brenner, W., Weikel, W., Rahnenführer, J., Hengstler, J. G., Roth, W., Hasenburg, A., Stewen, K. & Schmidt, M. (2023). Discordance of HER2-Low between Primary Tumors and Matched Distant Metastases in Breast Cancer. Cancers. Published. https://doi.org/10.3390/cancers15051413

2022

Almstedt, K., Heimes, A.-S., Kappenberg, F., Battista, M. J., Lehr, H.-A., Krajnak, S., Lebrecht, A., Gehrmann, M., Stewen, K., Brenner, W., Weikel, W., Rahnenführer, J., Hengstler, J. G., Hasenburg, A., & Schmidt, M. (2022). Long-term prognostic significance of HER2-low and HER2-zero in node-negative breast cancer. The European Journal of Cancer, 173, 10–19. https://doi.org/10.1016/j.ejca.2022.06.012

Brecklinghaus, T., Albrecht, W., Duda, J. C., Kappenberg, F., Gründler, L., Edlund, K., Marchan, R., Ghallab, A., Cadenas, C., Rieck, A., Vartak, N., Tolosa, L., Castell, J. V., Gardner, I., Halilbasic, E., Trauner, M., Ullrich, A., Zeigerer, A., Demirci Turgunbayer, Ö., … Hengstler, J. G. (2022). In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay. Toxicology Letters, 368, 33–46. https://doi.org/10.1016/j.toxlet.2022.08.006

Brecklinghaus, T., Albrecht, W., Kappenberg, F., Duda, J. C., Vartak, N., Edlund, K., Marchan, R., Ghallab, A., Cadenas, C., Günther, G., Leist, M., Zhang, M., Gardner, I., Reinders, J., Russel, F. GM., Foster, A. J., Williams, D. P., Damle-Vartak, A., Grandits, M., … Hengstler, J. G. (2022). The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chemico-Biological Interactions, 351, Article 109728. https://doi.org/10.1016/j.cbi.2021.109728

Brecklinghaus, T., Albrecht, W., Kappenberg, F., Duda, J. C., Zhang, M., Gardner, I., Marchan, R., Ghallab, A., Turgunbayer, Ö. D., Rahnenführer, J., & Hengstler, J. G. (2022). Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes. Toxicology in Vitro, 81, Article 105344. https://doi.org/10.1016/j.tiv.2022.105344

Cherianidou, A., Seidel, F., Kappenberg, F., Dreser, N., Blum, J., Waldmann, T., Blüthgen, N., Meisig, J., Madjar, K., Henry, M., Rotshteyn, T., Marchan, R., Edlund, K., Leist, M., Rahnenführer, J., Sachinidis, A., & Hengstler, J. G. (2022). Classification of developmental toxicants in a human iPSC transcriptomics-based test. Chemical Research in Toxicology, 35(5), 760–773. https://doi.org/10.1021/acs.chemrestox.1c00392

Duda, J. C., Kappenberg, F., & Rahnenführer, J. (2022). Model selection characteristics when using MCP‐Mod for dose–response gene expression data. Biometrical Journal, 64(5), 883–897. https://doi.org/10.1002/bimj.202000250

Ghallab, A., Hassan, R., Hofmann, U., Friebel, A., Hobloss, Z., Brackhagen, L., Begher-Tibbe, B., Myllys, M., Reinders, J., Overbeck, N. C., Sezgin, S., Zühlke, S., Seddek, A., Murad, W., Brecklinghaus, T., Kappenberg, F., Rahnenführer, J., González Leiva, D. F., Goldring, C., … Hengstler, J. G. (2022). Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity [OnlineRessource]. Journal of Hepatology, 77(1), 71–83. https://doi.org/10.1016/j.jhep.2022.01.020

Möllenhoff, K., Schorning, K., Kappenberg, F., & Kappenberg, F. (2022). Identifying alert concentrations using a model‐based bootstrap approach. Biometrics [ISSN: 0006-341X]. Published. https://doi.org/10.1111/biom.13799

Seidel, F., Cherianidou, A., Kappenberg, F., Marta, M., Dreser, N., Blum, J., Waldmann, T., Blüthgen, N., Meisig, J., Madjar, K., Henry, M., Rotshteyn, T., Scholtz-Illigens, A., Marchan, R., Edlund, K., Leist, M., Rahnenführer, J., Sachinidis, A., & Hengstler, J. G. (2022). High accuracy classification of developmental toxicants by in vitro tests of human neuroepithelial and cardiomyoblast differentiation. Cells, 11(21), Article 3404. https://doi.org/10.3390/cells11213404

2021

Ghallab, A., Myllys, M., Friebel, A., Duda, J. C., Edlund, K., Halilbasic, E., Vucur, M., Hobloss, Z., Brackhagen, L., Begher-Tibbe, B., Hassan, R., Burke, M., Genc, E., Frohwein, L. J., Hofmann, U., Holland, C. H., González Leiva, D. F., Keller, M., Seddek, A., … Hengstler, J. G. (2021). Spatio-temporal multiscale analysis of Western diet-fed mice reveals a translationally relevant sequence of events during NAFLD progression [OnlineRessource]. Cells, 10(10), Article 2516. https://doi.org/10.3390/cells10102516

Kappenberg, F., Grinberg, M., Jiang, X., Kopp-Schneider, A., Hengstler, J. G., & Rahnenführer, J. (2021). Comparison of observation-based and model-based identification of alert concentrations from concentration–expression data. Bioinformatics, 37(14), 1990–1996. https://doi.org/10.1093/bioinformatics/btab043

Kappenberg, F., Rahnenführer, J., & Schorning, K. (2021). Statistical approaches for calculating alert concentrations from cytotoxicity and gene expression data (Publisher’s Version) [Universitätsbibliothek Dortmund]. https://doi.org/10.17877/de290r-22150

2020

Kappenberg, F., Brecklinghaus, T., Albrecht, W., Blum, J., van der Wurp, C., Leist, M., Hengstler, J. G., & Rahnenführer, J. (2020). Handling deviating control values in concentration-response curves. Archives of Toxicology, 94(11), 3787–3798. https://doi.org/10.1007/s00204-020-02913-0

Kappenberg, F., & Rahnenführer, J. (2020). Dose‐response analysis using R , Ritz, C. , Jensen, S. M. , Gerhard, D. , Streibig, J. C. (2019). Boca Raton, FL: CRC Press, 214 pages. ISBN: 978‐1‐138‐03431‐0.: book review [Review of Dose‐response analysis using R , Ritz, C. , Jensen, S. M. , Gerhard, D. , Streibig, J. C. (2019). Boca Raton, FL: CRC Press, 214 pages. ISBN: 978‐1‐138‐03431‐0.: book review]. Biometrical Journal, 62(4), 1124–1125. Wiley-VCH. https://doi.org/10.1002/bimj.202000099

2019

Albrecht, W., Kappenberg, F., Brecklinghaus, T., Stöber, R., Marchan, R., Zhang, M., Ebbert, K., Kirschner, H., Grinberg, M., Leist, M., Moritz, W., Cadenas, C., Ghallab, A., Reinders, J., Vartak, N., Thriel, C. van, Golka, K., Tolosa, L., Castell, J. V., … Hengstler, J. G. (2019). Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Archives of Toxicology, 93(6), 1609–1637. https://doi.org/10.1007/s00204-019-02492-9

Krebs, A., Nyffeler, J., Karreman, C., Schmidt, B. Z., Kappenberg, F., Mellert, J., Pallocca, G., Pastor, M., Rahnenführer, J., & Leist, M. (2019). Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays. Alternatives to Animal Experimentation, 37(1), 155–163. https://doi.org/10.14573/altex.1912021

2018

Gu, X., Albrecht, W., Edlund, K., Kappenberg, F., Rahnenführer, J., Leist, M., Moritz, W., Godoy, P., Cadenas, C., Marchan, R., Brecklinghaus, T., Pardo, L. T., Castell, J. V., Gardner, I., Han, B., Hengstler, J. G., & Stoeber, R. (2018). Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes. Archives of Toxicology, 92(12), 3505–3515. https://doi.org/10.1007/s00204-018-2302-0

 

  • SuSe 2023: Exercises for "Klinische Studien", Seminar "Multiples Testen in der Biostatistik"
  • WiSe 2022/2023: "Introductory Case Studies"
  • SuSe 2022: "Statistics in Toxicology I (Modelling)"
  • WiSe 2021/2022 Exercises for "Statistics in Genetics (Bioinformatics)"
  • SuSe 2021: "Statistics in Toxicology I (Modelling)"
  • WiSe 2020/2021: Co-supervision for "Fallstudien I"
  • SuSe 2020: Exercises for "Klinische Studien", Co-supervision of the seminar "Biostatistik"
  • WiSe 2019: Exercises for "Statistics in Toxicology"
  • WiSe 2018/2019: Co-supervision of the seminar "Statistik in der Toxikologie"
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Location & approach

The campus of TU Dort­mund Uni­ver­sity is located close to interstate junction Dort­mund West, where the Sauerlandlinie A45 (Frankfurt-Dort­mund) crosses the Ruhrschnellweg B1 / A40. The best interstate exit to take from A45 is “Dort­mund-Eichlinghofen” (closer to South Cam­pus), and from B1 / A40 “Dort­mund-Dorstfeld” (closer to North Cam­pus). Signs for the uni­ver­si­ty are located at both exits. Also, there is a new exit before you pass over the B1-bridge leading into Dort­mund.

For travelling to the Department of Statistics, convenient parking places can be found at Vogelpothsweg (Gates 21 / 24) or alternatively at the Otto-Hahn-Straße (Gates 28 / 30 / 35).

TU Dort­mund Uni­ver­sity has its own train station (“Dort­mund Uni­ver­si­tät”). From there, suburban trains (S-Bahn) leave for Dort­mund main station (“Dort­mund Hauptbahnhof”) and Düsseldorf main station via the “Düsseldorf Airport Train Station” (take S-Bahn number 1, which leaves every 15 or 30 minutes). The uni­ver­si­ty is easily reached from Bo­chum, Essen, Mülheim an der Ruhr and Duis­burg.

You can also take the bus or subway train from Dort­mund city to the uni­ver­si­ty: From Dort­mund main station, you can take any train bound for the Station “Stadtgarten”, usually lines U41, U45, U 47 and U49. At “Stadtgarten” you switch trains and get on line U42 towards “Hombruch”. Look out for the Station “An der Palmweide”. From the bus stop just across the road, busses bound for TU Dort­mund Uni­ver­sity leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dort­mund main station to the stop “Dort­mund Kampstraße”. From there, take U43 or U44 to the stop “Dort­mund Wittener Straße”. Switch to bus line 447 and get off at “Dort­mund Uni­ver­si­tät S”.

The H-Bahn is one of the hallmarks of TU Dort­mund Uni­ver­sity. There are two stations on North Cam­pus. One (“Dort­mund Uni­ver­si­tät S”) is directly located at the suburban train stop, which connects the uni­ver­si­ty directly with the city of Dort­mund and the rest of the Ruhr Area. Also from this station, there are connections to the “Technologiepark” and (via South Cam­pus) Eichlinghofen. The other station is located at the dining hall at North Cam­pus and offers a direct connection to South Cam­pus every five minutes.

The AirportExpress is a fast and convenient means of transport from Dort­mund Airport (DTM) to Dort­mund Central Station, taking you there in little more than 20 minutes. From Dort­mund Central Station, you can continue to the uni­ver­si­ty campus by interurban railway (S-Bahn). A larger range of in­ter­na­tio­nal flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the uni­ver­si­ty station.

Interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

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