Dr. Franziska Kappenberg
Contact
TU Dortmund University
Department of Statistics
Statistical Methods in Genetics and Chemometrics
Mathematics Building, Room 713
44221 Dortmund
Germany
E-Mail: kappenbergstatistik.tu-dortmundde
Phone: +49 231 755 5908

- Dr. rer. nat (Statistics): TU Dortmund University, 2021
Thesis: Statistical approaches for calculating alert concentrations from cytotoxicity and gene expression data - M.Sc. (Statistics): TU Dortmund University, 2018
Master thesis: Vorhersage von Lebertoxizität aus Genexpressionsdaten - B.Sc. (Mathematics): Rheinische Friedrich-Wilhelms-Universität Bonn, 2015
Bachelor thesis: Das Gesetz des iterierten Logarithmus für die Irrfahrt auf dem unendlichen Perkolationscluster
Scientific Work
- since April 2021: Postdoc at the Department of Statistics
- April 2018 - March 2021: Research Assistant and doctoral student at the Department of Statistics
- August 2017 - March 2017: Student research assistant at the Department of Statistics
- Analysis of gene expression data
- Statistical methods in toxicology
- Modeling of dose-response curves
- Classification and prediction of liver and neurotoxicity
Previous project work:
- Since 2021: DFG-funded research training group 2624 "Biostatistical Methods for High-Dimensional Data in Toxicology"
- 2020: BMBF project "SysDT"
- 2018-2020: BMBF project "LivSys Transfer"
2023
Almstedt, K., Krauthauser, L., Kappenberg, F., Wagner, D.-C., Heimes, A.-S., Battista, M. J., Anic, K., Krajnak, S., Lebrecht, A., Schwab, R., Brenner, W., Weikel, W., Rahnenführer, J., Hengstler, J. G., Roth, W., Hasenburg, A., Stewen, K. & Schmidt, M. (2023). Discordance of HER2-Low between Primary Tumors and Matched Distant Metastases in Breast Cancer. Cancers. Published. https://doi.org/10.3390/cancers15051413
2022
Almstedt, K., Heimes, A.-S., Kappenberg, F., Battista, M. J., Lehr, H.-A., Krajnak, S., Lebrecht, A., Gehrmann, M., Stewen, K., Brenner, W., Weikel, W., Rahnenführer, J., Hengstler, J. G., Hasenburg, A., & Schmidt, M. (2022). Long-term prognostic significance of HER2-low and HER2-zero in node-negative breast cancer. The European Journal of Cancer, 173, 10–19. https://doi.org/10.1016/j.ejca.2022.06.012
Brecklinghaus, T., Albrecht, W., Duda, J. C., Kappenberg, F., Gründler, L., Edlund, K., Marchan, R., Ghallab, A., Cadenas, C., Rieck, A., Vartak, N., Tolosa, L., Castell, J. V., Gardner, I., Halilbasic, E., Trauner, M., Ullrich, A., Zeigerer, A., Demirci Turgunbayer, Ö., … Hengstler, J. G. (2022). In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay. Toxicology Letters, 368, 33–46. https://doi.org/10.1016/j.toxlet.2022.08.006
Brecklinghaus, T., Albrecht, W., Kappenberg, F., Duda, J. C., Vartak, N., Edlund, K., Marchan, R., Ghallab, A., Cadenas, C., Günther, G., Leist, M., Zhang, M., Gardner, I., Reinders, J., Russel, F. GM., Foster, A. J., Williams, D. P., Damle-Vartak, A., Grandits, M., … Hengstler, J. G. (2022). The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds. Chemico-Biological Interactions, 351, Article 109728. https://doi.org/10.1016/j.cbi.2021.109728
Brecklinghaus, T., Albrecht, W., Kappenberg, F., Duda, J. C., Zhang, M., Gardner, I., Marchan, R., Ghallab, A., Turgunbayer, Ö. D., Rahnenführer, J., & Hengstler, J. G. (2022). Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes. Toxicology in Vitro, 81, Article 105344. https://doi.org/10.1016/j.tiv.2022.105344
Cherianidou, A., Seidel, F., Kappenberg, F., Dreser, N., Blum, J., Waldmann, T., Blüthgen, N., Meisig, J., Madjar, K., Henry, M., Rotshteyn, T., Marchan, R., Edlund, K., Leist, M., Rahnenführer, J., Sachinidis, A., & Hengstler, J. G. (2022). Classification of developmental toxicants in a human iPSC transcriptomics-based test. Chemical Research in Toxicology, 35(5), 760–773. https://doi.org/10.1021/acs.chemrestox.1c00392
Duda, J. C., Kappenberg, F., & Rahnenführer, J. (2022). Model selection characteristics when using MCP‐Mod for dose–response gene expression data. Biometrical Journal, 64(5), 883–897. https://doi.org/10.1002/bimj.202000250
Ghallab, A., Hassan, R., Hofmann, U., Friebel, A., Hobloss, Z., Brackhagen, L., Begher-Tibbe, B., Myllys, M., Reinders, J., Overbeck, N. C., Sezgin, S., Zühlke, S., Seddek, A., Murad, W., Brecklinghaus, T., Kappenberg, F., Rahnenführer, J., González Leiva, D. F., Goldring, C., … Hengstler, J. G. (2022). Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity [OnlineRessource]. Journal of Hepatology, 77(1), 71–83. https://doi.org/10.1016/j.jhep.2022.01.020
Möllenhoff, K., Schorning, K., Kappenberg, F., & Kappenberg, F. (2022). Identifying alert concentrations using a model‐based bootstrap approach. Biometrics [ISSN: 0006-341X]. Published. https://doi.org/10.1111/biom.13799
Seidel, F., Cherianidou, A., Kappenberg, F., Marta, M., Dreser, N., Blum, J., Waldmann, T., Blüthgen, N., Meisig, J., Madjar, K., Henry, M., Rotshteyn, T., Scholtz-Illigens, A., Marchan, R., Edlund, K., Leist, M., Rahnenführer, J., Sachinidis, A., & Hengstler, J. G. (2022). High accuracy classification of developmental toxicants by in vitro tests of human neuroepithelial and cardiomyoblast differentiation. Cells, 11(21), Article 3404. https://doi.org/10.3390/cells11213404
2021
Ghallab, A., Myllys, M., Friebel, A., Duda, J. C., Edlund, K., Halilbasic, E., Vucur, M., Hobloss, Z., Brackhagen, L., Begher-Tibbe, B., Hassan, R., Burke, M., Genc, E., Frohwein, L. J., Hofmann, U., Holland, C. H., González Leiva, D. F., Keller, M., Seddek, A., … Hengstler, J. G. (2021). Spatio-temporal multiscale analysis of Western diet-fed mice reveals a translationally relevant sequence of events during NAFLD progression [OnlineRessource]. Cells, 10(10), Article 2516. https://doi.org/10.3390/cells10102516
Kappenberg, F., Grinberg, M., Jiang, X., Kopp-Schneider, A., Hengstler, J. G., & Rahnenführer, J. (2021). Comparison of observation-based and model-based identification of alert concentrations from concentration–expression data. Bioinformatics, 37(14), 1990–1996. https://doi.org/10.1093/bioinformatics/btab043
Kappenberg, F., Rahnenführer, J., & Schorning, K. (2021). Statistical approaches for calculating alert concentrations from cytotoxicity and gene expression data (Publisher’s Version) [Universitätsbibliothek Dortmund]. https://doi.org/10.17877/de290r-22150
2020
Kappenberg, F., Brecklinghaus, T., Albrecht, W., Blum, J., van der Wurp, C., Leist, M., Hengstler, J. G., & Rahnenführer, J. (2020). Handling deviating control values in concentration-response curves. Archives of Toxicology, 94(11), 3787–3798. https://doi.org/10.1007/s00204-020-02913-0
Kappenberg, F., & Rahnenführer, J. (2020). Dose‐response analysis using R , Ritz, C. , Jensen, S. M. , Gerhard, D. , Streibig, J. C. (2019). Boca Raton, FL: CRC Press, 214 pages. ISBN: 978‐1‐138‐03431‐0.: book review [Review of Dose‐response analysis using R , Ritz, C. , Jensen, S. M. , Gerhard, D. , Streibig, J. C. (2019). Boca Raton, FL: CRC Press, 214 pages. ISBN: 978‐1‐138‐03431‐0.: book review]. Biometrical Journal, 62(4), 1124–1125. Wiley-VCH. https://doi.org/10.1002/bimj.202000099
2019
Albrecht, W., Kappenberg, F., Brecklinghaus, T., Stöber, R., Marchan, R., Zhang, M., Ebbert, K., Kirschner, H., Grinberg, M., Leist, M., Moritz, W., Cadenas, C., Ghallab, A., Reinders, J., Vartak, N., Thriel, C. van, Golka, K., Tolosa, L., Castell, J. V., … Hengstler, J. G. (2019). Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Archives of Toxicology, 93(6), 1609–1637. https://doi.org/10.1007/s00204-019-02492-9
Krebs, A., Nyffeler, J., Karreman, C., Schmidt, B. Z., Kappenberg, F., Mellert, J., Pallocca, G., Pastor, M., Rahnenführer, J., & Leist, M. (2019). Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays. Alternatives to Animal Experimentation, 37(1), 155–163. https://doi.org/10.14573/altex.1912021
2018
Gu, X., Albrecht, W., Edlund, K., Kappenberg, F., Rahnenführer, J., Leist, M., Moritz, W., Godoy, P., Cadenas, C., Marchan, R., Brecklinghaus, T., Pardo, L. T., Castell, J. V., Gardner, I., Han, B., Hengstler, J. G., & Stoeber, R. (2018). Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes. Archives of Toxicology, 92(12), 3505–3515. https://doi.org/10.1007/s00204-018-2302-0
- SuSe 2023: Exercises for "Klinische Studien", Seminar "Multiples Testen in der Biostatistik"
- WiSe 2022/2023: "Introductory Case Studies"
- SuSe 2022: "Statistics in Toxicology I (Modelling)"
- WiSe 2021/2022 Exercises for "Statistics in Genetics (Bioinformatics)"
- SuSe 2021: "Statistics in Toxicology I (Modelling)"
- WiSe 2020/2021: Co-supervision for "Fallstudien I"
- SuSe 2020: Exercises for "Klinische Studien", Co-supervision of the seminar "Biostatistik"
- WiSe 2019: Exercises for "Statistics in Toxicology"
- WiSe 2018/2019: Co-supervision of the seminar "Statistik in der Toxikologie"
Search & People Search
Location & approach
The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B1 / A40. The best interstate exit to take from A45 is “Dortmund-Eichlinghofen” (closer to South Campus), and from B1 / A40 “Dortmund-Dorstfeld” (closer to North Campus). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B1-bridge leading into Dortmund.
For travelling to the Department of Statistics, convenient parking places can be found at Vogelpothsweg (Gates 21 / 24) or alternatively at the Otto-Hahn-Straße (Gates 28 / 30 / 35).
TU Dortmund University has its own train station (“Dortmund Universität”). From there, suburban trains (S-Bahn) leave for Dortmund main station (“Dortmund Hauptbahnhof”) and Düsseldorf main station via the “Düsseldorf Airport Train Station” (take S-Bahn number 1, which leaves every 15 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station “Stadtgarten”, usually lines U41, U45, U 47 and U49. At “Stadtgarten” you switch trains and get on line U42 towards “Hombruch”. Look out for the Station “An der Palmweide”. From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop “Dortmund Kampstraße”. From there, take U43 or U44 to the stop “Dortmund Wittener Straße”. Switch to bus line 447 and get off at “Dortmund Universität S”.
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on North Campus. One (“Dortmund Universität S”) is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the “Technologiepark” and (via South Campus) Eichlinghofen. The other station is located at the dining hall at North Campus and offers a direct connection to South Campus every five minutes.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
Interactive map
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".
